Schistosomiasis is an acute and chronic, parasitic disease caused by blood flukes (trematode worms) of the genus Schistosoma. At least 206 million people required treatment in 2016. Treatment, which should be repeated over a number of years, will reduce and prevent morbidity. The WHO strategy for schistosomiasis control focuses on reducing disease morbidity through periodic, targeted treatment with praziquantel. This involves regular treatment of all who are at-risk.