The World Health Organization (WHO) has been providing technical assistance to the Government of Republic of Maldives to strengthen country’s public health system since 1965. In this fourth Country Cooperation Strategy (CCS 2018–2022), the strategic priorities and the focus areas were designed for WHO’s engagement to complement the health system development efforts of the government and provide demand-driven policy and technical support. The WHO country cooperation will support mainstreaming of the SDGs into the national plans and enhance their implementation process to address the new health challenges including environmental and social determinants of health. This CCS has been developed based on the lessons learnt from the previous CCS and extensive consultations with the government and other stakeholders. The CCS is guided by the National Health Master Plan (2016–2025), the Thirteenth WHO General Programme of Work (GPW 2019–2023), Regional Flagship Programmes and it complements the United Nations Development Assistance Framework (UNDAF) for Maldives (2016–2020).